Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 8/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18517677 | 0.84 | RORC (0.40) | ALDH1A1 | |
| SCHEMBL13467314 | 0.83 | DPP8 (0.35) | HDAC4BACE1BACE2HCRTR1HCRTR2 | |
| SCHEMBL12693426 | 0.83 | DPP8 (0.35) | HDAC4BACE1BACE2HCRTR1HCRTR2 | |
| SCHEMBL8515221 | 0.80 | BACE1 (0.35) | HDAC4HCAR2BACE1BACE2CHRNA7 | |
| SCHEMBL8515218 | 0.80 | BACE1 (0.35) | HDAC4HCAR2BACE1BACE2CHRNA7 | |
| SCHEMBL16292152 | 0.80 | BACE1 (0.42) | BACE1BACE2 | |
| SCHEMBL12690086 | 0.73 | BACE1 (0.32) | BACE1BACE2 | |
| SCHEMBL12693428 | 0.73 | GAA (0.33) | HDAC4BACE1BACE2EPHX2SCN9A | |
| SCHEMBL989768 | 0.72 | HDAC4 (0.37) | HDAC4HCAR2BACE1BACE2CHRNA7 | |
| SCHEMBL8515667 | 0.68 | HCAR2 (0.36) | HDAC4HCAR2BACE1BACE2HDAC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3334738-A1 | 2-AMINO-7A-PHENYL-3,4,4A,5,7,7A-HEXAHYDROFURO[3,4-B]PYRIDINES AS BACE1 INHIBITORS | H. Lundbeck A/S (DK) | 2018-06-20 | — | — | EP | disclosed |
| WO-2017025565-A1 | 2-AMINO-7A-PHENYL-3,4,4A,5,7,7A-HEXAHYDROFURO[3,4-B]PYRIDINES AS BACE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2017-02-16 | — | — | WO | disclosed |