SCHEMBL9898656

SCHEMBL9898656

CCC(CC(=O)c1ccccc1)=NO[Si](C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.47
MEN1 O00255 4/20 0.47
HPGD P15428 3/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
CYP3A4 P08684 2/20 0.47
MAPT P10636 2/20 0.47
CES1 P23141 2/20 0.47
KDM4E B2RXH2 1/20 0.47
ALOX15 P16050 1/20 0.47
MAPK1 P28482 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
NPC1 O15118 5/20 0.44
RAB9A P51151 4/20 0.44
PLOD2 O00469 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
PLOD3 O60568 1/20 0.44
ALDH1A1 P00352 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9898655 1.00 KMT2A (0.47) KMT2AMEN1HPGDSMN1; SMN2CYP3A4
SCHEMBL9902144 0.92 KMT2A (0.52) KMT2AMEN1HPGDSMN1; SMN2CYP3A4
SCHEMBL9899411 0.88 KMT2A (0.44) KMT2AMEN1HPGDSMN1; SMN2CYP3A4
SCHEMBL9899410 0.88 KMT2A (0.44) KMT2AMEN1HPGDSMN1; SMN2CYP3A4
SCHEMBL9898288 0.85 KMT2A (0.44) KMT2AMEN1HPGDSMN1; SMN2CYP3A4
SCHEMBL9898290 0.85 KMT2A (0.44) KMT2AMEN1HPGDSMN1; SMN2CYP3A4
SCHEMBL2050491 0.83 ATM (0.44) KMT2AMEN1SMN1; SMN2MAPTCES1
SCHEMBL2050492 0.83 ATM (0.44) KMT2AMEN1SMN1; SMN2MAPTCES1
SCHEMBL9898692 0.83 KMT2A (0.52) KMT2AMEN1HPGDSMN1; SMN2CYP3A4
SCHEMBL9898694 0.83 KMT2A (0.52) KMT2AMEN1HPGDSMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748531-B2 Polymers functionalized with oxime compounds containing an acyl group BRIDGESTONE CORPORATION (JP) 2014-06-10 US claimed
US-20120149833-A1 POLYMERS FUNCTIONALIZED WITH OXIME COMPOUNDS CONTAINING AN ACYL GROUP BRIDGESTONE CORPORATION (JP) 2012-06-14 US claimed
EP-2649102-B1 POLYMERS FUNCTIONALIZED WITH OXIME COMPOUNDS CONTAINING AN ACYL GROUP BRIDGESTONE CORP (JP) 2014-11-26 EP disclosed
US-8748531-B2 Polymers functionalized with oxime compounds containing an acyl group BRIDGESTONE CORPORATION (JP) 2014-06-10 US disclosed
US-20120149833-A1 POLYMERS FUNCTIONALIZED WITH OXIME COMPOUNDS CONTAINING AN ACYL GROUP BRIDGESTONE CORPORATION (JP) 2012-06-14 US disclosed