Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 10/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.50 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.49 |
| ▸ | GCGR | P47871 | 3/20 | 0.49 |
| ▸ | RAF1 | P04049 | 6/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5985861 | 0.85 | MAPK14 (0.46) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL989125 | 0.81 | MAPK14 (0.46) | MAPK13MAPK12MAPK11MAPK14NOX1 | |
| SCHEMBL989883 | 0.79 | HDAC1 (0.37) | MAPK14KDM4EALDH1A1GAAHPGD | |
| SCHEMBL11696736 | 0.77 | HDAC2 (0.57) | KDM4EALDH1A1GAAHPGDKMT2A | |
| SCHEMBL989296 | 0.74 | MAPK14 (0.52) | MAPK14 | |
| SCHEMBL5074753 | 0.73 | MAPK13 (0.83) | MAPK13MAPK12MAPK11MAPK14NOX1 | |
| SCHEMBL3409732 | 0.72 | MAPK14 (0.71) | MAPK13MAPK12MAPK11MAPK14NOX1 | |
| SCHEMBL16667652 | 0.72 | MAPK13 (0.83) | MAPK13MAPK12MAPK11MAPK14NOX1 | |
| SCHEMBL104130 | 0.72 | MAPK13 (0.82) | MAPK13MAPK12MAPK11MAPK14NOX1 | |
| Benzene SCHEMBL28852698 | 0.72 | MAPK13 (0.82) | MAPK13MAPK12MAPK11MAPK14NOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863310-B2 | Kinase inhibitors | ELI LILLY AND COMPANY (US) | 2011-01-04 | — | — | US | disclosed |
| US-20080227839-A1 | Kinase Inhibitors | ELI LILLY AND COMPANY | 2008-09-18 | — | — | US | disclosed |
| EP-1720862-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005080380-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227839-A1 | Kinase Inhibitors | ABL1, MAP3K20, MAP3K19 | MAPK13 249/4885MAPK12 290/4885MAPK11 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.