Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9904051 | 1.00 | HDAC4 (0.42) | HDAC4HDAC6LMNAALDH1A1HTT | |
| SCHEMBL1904264 | 1.00 | HDAC4 (0.42) | HDAC4HDAC6LMNAALDH1A1HTT | |
| SCHEMBL517391 | 0.89 | CYP4F2 (0.39) | HDAC4HDAC6LMNAALDH1A1HTT | |
| SCHEMBL1904315 | 0.89 | PDE2A (0.39) | HDAC4HDAC6LMNAHTTSMN1; SMN2 | |
| SCHEMBL11932087 | 0.88 | KMT2A (0.40) | LMNAALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL6899887 | 0.88 | SMN1; SMN2 (0.47) | LMNAALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL517023 | 0.88 | KMT2A (0.40) | LMNAALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL11932093 | 0.87 | MAPT (0.41) | LMNAALDH1A1HTTSMN1; SMN2NPC1 | |
| SCHEMBL28016609 | 0.87 | MAPT (0.41) | LMNAALDH1A1HTTSMN1; SMN2NPC1 | |
| SCHEMBL16748974 | 0.87 | MAPT (0.41) | LMNAALDH1A1HTTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649045-A2 | SUBSTITUTED 1-BENZYLCYCLOALKYLCARBOXLIC ACIDS AND USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076466-A2 | SUBSTITUTED 1-BENZYLCYCLOALKYLCARBOXLIC ACIDS AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-14 | — | — | WO | disclosed |