⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5323324 | 1.00 | — | — | |
| SCHEMBL9004334 | 0.81 | CHRM2 (0.34) | — | |
| SCHEMBL15131434 | 0.80 | ALDH1A1 (0.31) | — | |
| SCHEMBL15094274 | 0.80 | — | — | |
| SCHEMBL6625272 | 0.75 | — | — | |
| SCHEMBL11590682 | 0.75 | — | — | |
| SCHEMBL16409821 | 0.73 | — | — | |
| SCHEMBL17548413 | 0.73 | — | — | |
| SCHEMBL19397921 | 0.73 | — | — | |
| SCHEMBL159311 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250171459-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMA (US) | 2025-05-29 | — | — | US | disclosed |
| CN-119343353-A | 2-Methyl-4 ',5' -dihydrospiro [ piperidine-4, 7' -thieno [2,3-c ] pyran ] derivatives as APOL1 inhibitors and methods of use thereof | 弗特克斯药品有限公司 | 2025-01-21 | — | — | CN | disclosed |
| US-20240417388-A1 | BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 | CANCER RESEARCH TECH LTD (GB) | 2024-12-19 | — | — | US | disclosed |
| EP-4476227-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | Vertex Pharmaceuticals Incorporated (US) | 2024-12-18 | — | — | EP | disclosed |
| US-12110286-B2 | Benzimidazolone derived inhibitors of BCL6 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-10-08 | — | — | US | disclosed |
| CN-118561812-A | Benzimidazolone-derived BCL6 inhibitors | 癌症研究科技有限公司 | 2024-08-30 | — | — | CN | disclosed |
| EP-3389783-B1 | NOVEL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-07-03 | — | — | EP | disclosed |
| EP-3389783-B1 | NOVEL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-07-03 | — | — | EP | disclosed |
| US-12017979-B2 | Molecules | Ena Respiratory Pty Ltd (AU) | 2024-06-25 | — | — | US | disclosed |
| EP-4374858-A2 | BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 | Cancer Research Technology Limited (GB) | 2024-05-29 | — | — | EP | disclosed |
| WO-2004098522-A2 | GEMINI VITAMIN D3 COMPOUNDS AND METHODS OF USE THEREOF | BIOXELL S.P.A. (IT) | 2004-11-18 | — | — | WO | disclosed |
| CN-1498132-A | Catalyst for producing both end-hydroxyl end-hydroxyl group.terminated diols,process for producing the catalyst,process for producing the diols by using the catalyst,and both end-hydroxyl group... | 昭和电工株式会社 | 2004-05-19 | — | — | CN | disclosed |
| US-20030119666-A1 | Catalyst for producing both end-hydroxyl group-terminated diols, process for producing the catalyst, process for producing the diols by using the catalyst, and both end-hydroxyl group-terminated diols obtained by the process | KADOWAKI YASUSHI (JP) | 2003-06-26 | — | — | US | disclosed |
| US-4968817-A | COBALT OR NICKEL CATALYST | NATIONAL DISTILLERS AND CHEMICAL CORPORATION (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0230600-B1 | PRODUCTION OF CHOLECALCIFEROL DERIVATIVES AND NOVEL INTERMEDIATES USED THEREFOR | Teva Pharmaceutical Industries Limited (IL) | 1990-06-27 | — | — | EP | disclosed |
| US-4758382-A | Process for the stereospecific preparation of 24(R),25- and 24(S),25-dihydroxycholecalciferol and novel intermediates used therefor | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1988-07-19 | — | — | US | disclosed |
| EP-0230600-A1 | Production of cholecalciferol derivatives and novel intermediates used therefor | Teva Pharmaceutical Industries Limited (IL) | 1987-08-05 | — | — | EP | disclosed |
| EP-0045524-B1 | 22-ARYLSULFONYL-24,25-DIHYDROXYCHOLESTANES AND PROCESS FOR PREPARING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1983-10-19 | — | — | EP | disclosed |
| US-4344888-A | 24,25-Dihydroxycholestans and process for preparing the same | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1982-08-17 | — | — | US | disclosed |
| EP-0045524-A1 | 22-Arylsulfonyl-24,25-dihydroxycholestanes and process for preparing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1982-02-10 | — | — | EP | disclosed |