Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 12/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12594090 | 0.92 | L3MBTL1 (0.57) | L3MBTL1GAAHSPB1MAPTALDH1A1 | |
| SCHEMBL13720426 | 0.88 | L3MBTL1 (0.56) | L3MBTL1GAAHSPB1MAPTALDH1A1 | |
| SCHEMBL29437987 | 0.85 | L3MBTL1 (0.59) | L3MBTL1GAAHSPB1MAPTALDH1A1 | |
| SCHEMBL12593964 | 0.85 | L3MBTL1 (0.59) | L3MBTL1GAAHSPB1MAPTALDH1A1 | |
| SCHEMBL13720843 | 0.85 | L3MBTL1 (0.54) | L3MBTL1GAAHSPB1MAPTALDH1A1 | |
| SCHEMBL29437962 | 0.85 | L3MBTL1 (0.53) | L3MBTL1GAAHSPB1MAPTALDH1A1 | |
| SCHEMBL1978325 | 0.85 | L3MBTL1 (0.53) | L3MBTL1GAAHSPB1MAPTALDH1A1 | |
| SCHEMBL13720336 | 0.83 | MAPT (0.55) | L3MBTL1GAAHSPB1MAPTALDH1A1 | |
| SCHEMBL29438001 | 0.83 | MAPT (0.55) | L3MBTL1GAAHSPB1MAPTALDH1A1 | |
| SCHEMBL10352701 | 0.82 | CYP19A1 (0.55) | GAAMAPTALDH1A1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |