Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | PLA2G7 | Q13093 | 4/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900919 | 0.76 | PLA2G7 (0.55) | NPBWR1PLA2G7USP2ALDH1A1CYP1A2 | |
| SCHEMBL9106670 | 0.75 | PLA2G7 (0.39) | PLA2G7USP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9109715 | 0.66 | SMN1; SMN2 (0.44) | NPBWR1MCHR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9107499 | 0.64 | PDE4B (0.40) | ALDH1A1 | |
| SCHEMBL9108853 | 0.62 | PLA2G7 (0.49) | PLA2G7 | |
| SCHEMBL9889539 | 0.62 | ST14 (0.34) | — | |
| SCHEMBL9104512 | 0.62 | PLA2G7 (0.36) | GPR84PLA2G7ALDH1A1SMN1; SMN2 | |
| SCHEMBL9109709 | 0.61 | SOS1 (0.33) | NPBWR1ALDH1A1 | |
| SCHEMBL9108589 | 0.60 | PLA2G7 (0.38) | PLA2G7USP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9105717 | 0.60 | PLA2G7 (0.41) | GRM2PLA2G7USP2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |