Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 6/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 4/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18235654 | 0.87 | PLA2G7 (0.48) | IDO1PPARGPPARAPLA2G7AR | |
| SCHEMBL875588 | 0.83 | IDO1 (0.51) | IDO1PPARGPPARAPLA2G7AR | |
| SCHEMBL875436 | 0.83 | POLB (0.44) | IDO1PPARGPPARAPLA2G7BRAF | |
| SCHEMBL4084168 | 0.82 | IDO1 (0.57) | IDO1PPARGPPARAGPR84KDR | |
| SCHEMBL9104268 | 0.82 | IDO1 (0.50) | IDO1PPARGPPARAPLA2G7AR | |
| SCHEMBL29918384 | 0.82 | IDO1 (0.50) | IDO1PPARGPPARAPLA2G7AR | |
| SCHEMBL29985730 | 0.82 | AR (0.46) | PPARGPPARAARCHEK2RAF1 | |
| SCHEMBL875004 | 0.82 | AR (0.46) | PPARGPPARAARCHEK2RAF1 | |
| SCHEMBL17884158 | 0.82 | IDO1 (0.50) | IDO1PPARGPPARAPLA2G7AR | |
| SCHEMBL875664 | 0.82 | IDO1 (0.50) | IDO1PPARGPPARAPLA2G7AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |