Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900903 | 0.94 | MAPKAPK2 (0.46) | MAPKAPK2MAPK14IDH1 | |
| SCHEMBL9902403 | 0.94 | MAPK14 (0.47) | MAPKAPK2MAPK14 | |
| SCHEMBL9110519 | 0.87 | MAPK14 (0.52) | MAPKAPK2MAPK14 | |
| SCHEMBL9902573 | 0.86 | MAPKAPK2 (0.45) | MAPKAPK2MAPK14 | |
| SCHEMBL9901165 | 0.85 | MAPK14 (0.48) | MAPKAPK2MAPK14 | |
| SCHEMBL9112050 | 0.83 | MAPKAPK2 (0.59) | MAPKAPK2MAPK14 | |
| SCHEMBL9112180 | 0.82 | MAPK14 (0.64) | MAPK14 | |
| SCHEMBL9902504 | 0.82 | GRM5 (0.32) | — | |
| SCHEMBL9901669 | 0.82 | MAOB (0.35) | — | |
| SCHEMBL9902228 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648516-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2013-10-16 | — | — | EP | claimed |
| WO-2012078684-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | claimed |
| EP-2648516-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078684-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |