Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905052 | 0.94 | BRD4 (0.32) | GRM5BRD4GABRG2GABRB3GABRA5 | |
| SCHEMBL9905063 | 0.93 | GRM5 (0.31) | GRM5 | |
| SCHEMBL9905322 | 0.91 | GABRG2 (0.31) | GRM5GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9109343 | 0.86 | MAPK14 (0.32) | GRM5BRD4GABRG2GABRB3GABRA5 | |
| SCHEMBL9901669 | 0.86 | MAOB (0.35) | — | |
| SCHEMBL9902228 | 0.86 | — | — | |
| SCHEMBL9902126 | 0.86 | NMT1 (0.37) | — | |
| SCHEMBL9901297 | 0.85 | BRD4 (0.31) | GRM5BRD4GABRG2GABRB3GABRA5 | |
| SCHEMBL9901203 | 0.85 | GABRG2 (0.30) | GRM5GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9902538 | 0.84 | MAOB (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648516-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2013-10-16 | — | — | EP | claimed |
| WO-2012078684-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | claimed |