Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 7/20 | 1.00 |
| ▸ | IDO1 | P14902 | 3/20 | 1.00 |
| ▸ | TDO2 | P48775 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.61 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.59 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.59 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.59 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900993 | 1.00 | TGM2 (1.00) | TGM2IDO1TDO2ALDH1A1LMNA | |
| SCHEMBL29136962 | 0.86 | TGM2 (0.76) | TGM2IDO1TDO2LRRK2CDYL2 | |
| SCHEMBL29136960 | 0.86 | TGM2 (0.76) | TGM2IDO1TDO2LRRK2CDYL2 | |
| SCHEMBL24739854 | 0.84 | TGM2 (0.72) | TGM2IDO1TDO2LRRK2CDYL2 | |
| SCHEMBL29879570 | 0.84 | TGM2 (0.72) | TGM2IDO1TDO2LRRK2CDYL2 | |
| SCHEMBL29137069 | 0.84 | TGM2 (0.72) | TGM2IDO1TDO2LRRK2CDYL2 | |
| SCHEMBL4858391 | 0.84 | TGM2 (0.72) | TGM2IDO1TDO2MAPTLRRK2 | |
| SCHEMBL4858381 | 0.84 | TGM2 (0.72) | TGM2IDO1TDO2MAPTLRRK2 | |
| SCHEMBL14446379 | 0.81 | TGM2 (0.68) | TGM2IDO1TDO2LRRK2PSEN1 | |
| SCHEMBL1534167 | 0.79 | LRRK2 (0.65) | TGM2IDO1TDO2MAPTLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078519-A2 | 3-ACYLIDENE-2-OXOINDOLE DERIVATIVES FOR INHIBITION OF TRANSGLUTAMINASE 2 | NUMERATE, INC. (US) | 2012-06-14 | — | — | WO | disclosed |