Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | GRB2 | P62993 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22444773 | 0.88 | SLC7A5 (0.53) | SLC7A5PTGS1ALOX15HIF1AKDM4E | |
| SCHEMBL17512862 | 0.86 | SLC7A5 (0.57) | SLC7A5PTGS1ALOX15HIF1AKDM4E | |
| SCHEMBL17512864 | 0.86 | SLC7A5 (0.57) | SLC7A5PTGS1ALOX15HIF1AKDM4E | |
| SCHEMBL4438009 | 0.86 | PPARG (0.56) | KDM4EPPARGPPARAIDO1KDR | |
| SCHEMBL4795847 | 0.84 | PPARG (0.53) | KDM4EPPARGPPARAIDO1KDR | |
| SCHEMBL2908984 | 0.84 | PPARG (0.53) | KDM4EPPARGPPARAIDO1KDR | |
| SCHEMBL5792765 | 0.84 | SLC7A5 (0.67) | SLC7A5PTGS1ALOX15HIF1AKDM4E | |
| SCHEMBL5792769 | 0.84 | SLC7A5 (0.67) | SLC7A5PTGS1ALOX15HIF1AKDM4E | |
| SCHEMBL3309849 | 0.81 | GRB2 (0.44) | SLC7A5PTGS1ALOX15HIF1AKDM4E | |
| SCHEMBL3309854 | 0.81 | GRB2 (0.44) | SLC7A5PTGS1ALOX15HIF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649050-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012075917-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |