Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.32 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905057 | 0.94 | MAPKAPK2 (0.38) | MAPKAPK2HDAC1HDAC6HDAC5BRD4 | |
| SCHEMBL9901068 | 0.93 | MAPKAPK2 (0.32) | MAPKAPK2BRD4JMJD6 | |
| SCHEMBL9905079 | 0.89 | MAPKAPK2 (0.34) | MAPKAPK2MAPKAPK5JMJD6 | |
| SCHEMBL9905211 | 0.89 | HDAC1 (0.32) | HDAC1HDAC6HDAC5BRD4JMJD6 | |
| SCHEMBL9109995 | 0.87 | MAPKAPK2 (0.48) | MAPKAPK2HDAC1HDAC6HDAC5MAPKAPK5 | |
| SCHEMBL9109001 | 0.84 | MAPKAPK2 (0.40) | MAPKAPK2BRD4MAPKAPK5JMJD6 | |
| SCHEMBL9901137 | 0.84 | MAPKAPK2 (0.36) | MAPKAPK2MAPKAPK5JMJD6 | |
| SCHEMBL9110839 | 0.82 | MAPKAPK5 (0.49) | MAPKAPK2MAPKAPK5 | |
| SCHEMBL9905480 | 0.81 | ALOX5AP (0.31) | BRD4JMJD6 | |
| SCHEMBL9112278 | 0.81 | MAPK14 (0.41) | MAPKAPK2MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648516-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078684-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |