Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | JMJD6 | Q6NYC1 | 3/20 | 0.31 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905480 | 0.93 | ALOX5AP (0.31) | BRD4ALOX5APFEN1JMJD6PFKFB3 | |
| SCHEMBL9901328 | 0.89 | MAPKAPK2 (0.37) | HDAC1HDAC6HDAC5BRD4JMJD6 | |
| SCHEMBL9111507 | 0.87 | MAPKAPK2 (0.38) | HDAC1HDAC6HDAC5BRD4JMJD6 | |
| SCHEMBL9905057 | 0.86 | MAPKAPK2 (0.38) | HDAC1HDAC6HDAC5BRD4JMJD6 | |
| SCHEMBL9905052 | 0.86 | BRD4 (0.32) | BRD4 | |
| SCHEMBL9905168 | 0.85 | NMT1 (0.40) | FEN1 | |
| SCHEMBL9905454 | 0.85 | JMJD6 (0.33) | BRD4ALOX5APFEN1JMJD6PFKFB3 | |
| SCHEMBL9111940 | 0.84 | JMJD6 (0.33) | BRD4JMJD6PFKFB3 | |
| SCHEMBL9901763 | 0.83 | MAOB (0.35) | BRD4 | |
| SCHEMBL9900903 | 0.81 | MAPKAPK2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648516-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2013-10-16 | — | — | EP | claimed |
| WO-2012078684-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | claimed |