SCHEMBL9901355

SCHEMBL9901355

N#CC(C#N)=CCCc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 1/20 0.42
TDP1 Q9NUW8 2/20 0.41
CYP1A1 P04798 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP1B1 Q16678 1/20 0.41
GPR52 Q9Y2T5 3/20 0.41
SNCA P37840 1/20 0.39
ALDH1A1 P00352 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
ALOX12 P18054 1/20 0.38
CASP1 P29466 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
KEAP1 Q14145 1/20 0.38
APP P05067 2/20 0.37
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
CYP2A6 P11509 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5879095 0.81 GRIK1 (0.41) GRIK1TDP1CYP1A1CYP1A2CYP1B1
SCHEMBL14312304 0.81 ALDH1A1 (0.41) GRIK1TDP1GPR52ALDH1A1HPGD
SCHEMBL3440752 0.81 ALDH1A1 (0.41) GRIK1TDP1GPR52ALDH1A1HPGD
SCHEMBL3440751 0.81 ALDH1A1 (0.41) GRIK1TDP1GPR52ALDH1A1HPGD
SCHEMBL10665830 0.79 MAOB (0.46) CYP1A1CYP1A2CYP1B1SNCAALDH1A1
SCHEMBL1274448 0.78 GRIK1 (0.49) GRIK1TDP1CYP1A2GPR52ALDH1A1
SCHEMBL8671784 0.77 LSS (0.39) TDP1SNCACA1CA2MAOA
SCHEMBL7168307 0.76 TDP1 (0.50) GRIK1TDP1GPR52ALDH1A1HPGD
SCHEMBL6053648 0.72 TDP1 (0.46) GRIK1TDP1GPR52ALDH1A1HPGD
SCHEMBL105976 0.72 TRPV1 (0.51) GRIK1TDP1GPR52ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3400213-A1 INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION Rijksuniversiteit Groningen (NL) 2018-11-14 EP disclosed
WO-2017118762-A1 INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION RIJKSUNIVERSITEIT GRONINGEN (NL) 2017-07-13 WO disclosed
EP-2648509-A2 SUBSTITUTED 4-(ARYLAMINO) SELENOPHENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF Kasina Laila Innova Pharmaceuticals Private Ltd. (IN) 2013-10-16 EP disclosed
WO-2012077135-A2 SUBSTITUTED 4-(ARYLAMINO) SELENOPHENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LIMITED (IN) 2012-06-14 WO disclosed