Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 7/20 | 0.41 |
| ▸ | CCNH | P51946 | 7/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 7/20 | 0.41 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.37 |
| ▸ | CDK9 | P50750 | 6/20 | 0.37 |
| ▸ | CCNK | O75909 | 5/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900735 | 0.80 | IDH2 (0.40) | CDK7CCNHMNAT1IDH2CCNT1 | |
| SCHEMBL22895721 | 0.78 | CDK7 (0.49) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL28541095 | 0.78 | CDK7 (0.49) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL9900288 | 0.73 | EHMT2 (0.42) | EHMT2MAPK1OPRK1CHEK1BRD4 | |
| SCHEMBL9900191 | 0.73 | CHRNB2 (0.39) | — | |
| SCHEMBL21604646 | 0.71 | EHMT2 (0.45) | CDK7CCNHMNAT1EHMT2IDH2 | |
| SCHEMBL21605843 | 0.71 | EHMT2 (0.45) | CDK7CCNHMNAT1EHMT2IDH2 | |
| SCHEMBL23292398 | 0.68 | CCNK (0.47) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL22895393 | 0.68 | CCNT1 (0.53) | CDK7CCNHMNAT1CCNT1CDK9 | |
| Hydrochloric Acid SCHEMBL28545061 | 0.68 | CCNT1 (0.53) | CDK7CCNHMNAT1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090593-B2 | Bicyclic compounds as Pim inhibitors | AMGEN INC. (US) | 2015-07-28 | — | — | US | claimed |
| EP-2796456-A1 | Bicyclic compounds as Pim inhibitors | Amgen Inc. (US) | 2014-10-29 | — | — | EP | claimed |
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2014-01-30 | — | — | US | claimed |
| EP-2649065-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2013-10-16 | — | — | EP | claimed |
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | claimed |
| US-9090593-B2 | Bicyclic compounds as Pim inhibitors | AMGEN INC. (US) | 2015-07-28 | — | — | US | disclosed |
| EP-2796456-A1 | Bicyclic compounds as Pim inhibitors | Amgen Inc. (US) | 2014-10-29 | — | — | EP | disclosed |
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | PIM1, PIM2, PIM3 | CDK7 639/4885CCNH 1763/4885MNAT1 543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.