Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 9/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29918343 | 0.87 | AR (0.50) | PLA2G7ARSCN9AHTR2ASLC6A4 | |
| SCHEMBL14656196 | 0.87 | AR (0.50) | PLA2G7ARSCN9AHTR2ASLC6A4 | |
| SCHEMBL24385994 | 0.85 | AR (0.46) | PLA2G7ARHTR2ASLC6A4KCNH2 | |
| SCHEMBL9104816 | 0.85 | PLA2G7 (0.47) | PLA2G7ARSCN9AHTR2ASLC6A4 | |
| SCHEMBL29918519 | 0.85 | PLA2G7 (0.47) | PLA2G7ARSCN9AHTR2ASLC6A4 | |
| SCHEMBL25737338 | 0.84 | PLA2G7 (0.56) | PLA2G7IDO1 | |
| SCHEMBL9104268 | 0.83 | IDO1 (0.50) | PLA2G7ARIDO1BRAF | |
| SCHEMBL24998717 | 0.80 | AR (0.46) | PLA2G7ARSCN9AHTR2ASLC6A4 | |
| SCHEMBL11990072 | 0.79 | SLC6A4 (0.48) | HTR2ASLC6A4KCNH2 | |
| SCHEMBL9107362 | 0.78 | SCN9A (0.45) | PLA2G7ARSCN9AHTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |