Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 5/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19725442 | 0.84 | MPO (0.37) | MPOARPDK2BCAT1L3MBTL1 | |
| SCHEMBL876038 | 0.80 | AR (0.39) | ARPDK2L3MBTL1MEN1KMT2A | |
| SCHEMBL17185834 | 0.77 | MPO (0.39) | MPOBCAT1L3MBTL1MEN1KMT2A | |
| SCHEMBL379748 | 0.77 | MPO (0.39) | MPOBCAT1L3MBTL1MEN1KMT2A | |
| SCHEMBL22904169 | 0.77 | MPO (0.39) | MPOPDK2BCAT1L3MBTL1MEN1 | |
| SCHEMBL19437188 | 0.77 | MPO (0.39) | MPOBCAT1L3MBTL1MEN1KMT2A | |
| SCHEMBL12507402 | 0.77 | MPO (0.39) | MPOBCAT1L3MBTL1MEN1KMT2A | |
| SCHEMBL16892266 | 0.76 | HTR2A (0.37) | MPOARBCAT1L3MBTL1MEN1 | |
| SCHEMBL21910132 | 0.74 | MPO (0.38) | MPOARBCAT1L3MBTL1MEN1 | |
| SCHEMBL4136617 | 0.73 | TAAR1 (0.33) | ARPGRKDM4EALDH1A1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |