SCHEMBL990242

SCHEMBL990242

CC(C)(C)OC(=O)NCC(Cc1ccccc1)C(=O)NO

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CTSS P25774 4/20 0.53
CTSK P43235 3/20 0.53
CTSL P07711 1/20 0.53
CTSB P07858 1/20 0.53
ATM Q13315 1/20 0.52
SYK P43405 1/20 0.52
PTPRB P23467 2/20 0.51
AKT1 P31749 1/20 0.47
MMP8 P22894 1/20 0.46
ACE P12821 1/20 0.46
IDO1 P14902 1/20 0.45
HDAC3 O15379 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
MME P08473 1/20 0.45
LTA4H P09960 1/20 0.45
ANPEP P15144 1/20 0.45
ECE1 P42892 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6600193 0.88 CTSS (0.52) CTSSCTSKCTSLCTSBATM
SCHEMBL825959 0.88 ATM (0.55) CTSSCTSKCTSLCTSBATM
SCHEMBL3825012 0.88 ATM (0.55) CTSSCTSKCTSLCTSBATM
SCHEMBL1186455 0.88 ATM (0.55) CTSSCTSKCTSLCTSBATM
SCHEMBL13816316 0.85 SYK (0.56) CTSSCTSKCTSLCTSBATM
SCHEMBL1185840 0.83 SYK (0.57) CTSSCTSKCTSLCTSBATM
SCHEMBL990687 0.83 ANPEP (0.45) CTSSCTSKCTSLCTSBATM
SCHEMBL21974545 0.82 SYK (0.56) CTSSCTSKCTSLCTSBATM
SCHEMBL13300083 0.82 CTSS (0.51) CTSSCTSKCTSLCTSBATM
SCHEMBL13114024 0.81 ATM (0.61) CTSSCTSKCTSLCTSBATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2456762-A1 DUAL-ACTING OXAZOLE ANTIHYPERTENSIVE AGENTS Theravance, Inc. (US) 2012-05-30 EP disclosed
WO-2011011232-A1 DUAL-ACTING OXAZOLE ANTIHYPERTENSIVE AGENTS THERAVANCE, INC. (US) 2011-01-27 WO disclosed