Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.66 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.66 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | BLM | P54132 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | ESR1 | P03372 | 1/20 | 0.66 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.66 |
| ▸ | FYN | P06241 | 1/20 | 0.66 |
| ▸ | PGR | P06401 | 1/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL201920 | 1.00 | CYSLTR1 (0.66) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL1150080 | 1.00 | CYSLTR1 (0.66) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL29903285 | 1.00 | CYSLTR1 (0.66) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL30205136 | 1.00 | CYSLTR1 (0.66) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL9926899 | 1.00 | CYSLTR1 (0.66) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL201921 | 1.00 | CYSLTR1 (0.66) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| Alcohol SCHEMBL2569564 | 0.97 | CYSLTR1 (0.64) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL2886354 | 0.95 | CYSLTR1 (0.63) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL2886360 | 0.95 | CYSLTR1 (0.63) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL28786456 | 0.95 | CYSLTR1 (0.63) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178841-B1 | PROCESS AND INTERMEDIATE FOR THE PRODUCTION OF A TERTIARY ALCOHOL AS AN INTERMEDIATE IN THE SYNTHESIS OF MONTELUKAST | LONZA AG (CH) | 2011-11-02 | — | — | EP | claimed |
| EP-2203557-A1 | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Codexis, Inc. (US) | 2010-07-07 | — | — | EP | claimed |
| EP-2094665-A2 | PREPARATION OF MONTELUKAST AND ITS SALTS | Dr. Reddy's Laboratories Ltd. (IN) | 2009-09-02 | — | — | EP | claimed |
| WO-2009042984-A1 | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | CODEXIS, INC. (US) | 2009-04-02 | — | — | WO | claimed |
| WO-2008058118-A2 | PREPARATION OF MONTELUKAST AND ITS SALTS | DR. REDDY'S LABORTORIES, LTD. (IN) | 2008-05-15 | — | — | WO | claimed |
| WO-2008023044-A1 | PROCESS FOR THE PREPARATION OF MONTELUKAST FREE ACID AND ITS AMINE SALTS | SANDOZ AG (CH) | 2008-02-28 | — | — | WO | claimed |
| US-12233055-B2 | Topical Montelukast formulations | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2025-02-25 | — | — | US | disclosed |
| US-11844861-B2 | Topical Montelukast formulations | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2023-12-19 | — | — | US | disclosed |
| US-20230248641-A1 | TOPICAL MONTELUKAST FOR TREATMENT OF ATOPIC DERMATITIS | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2023-08-10 | — | — | US | disclosed |
| CN-115710221-A | Synthesis method of montelukast sodium intermediate | 宿迁盛基医药科技有限公司 | 2023-02-24 | — | — | CN | disclosed |
| EP-4099982-A1 | TOPICAL MONTELUKAST FORMULATIONS | Taro Pharmaceutical Industries Ltd. (IL) | 2022-12-14 | — | — | EP | disclosed |
| CN-115038427-A | Topical montelukast formulations | 塔罗制药工业有限公司 | 2022-09-09 | — | — | CN | disclosed |
| US-20220016028-A1 | TOPICAL MONTELUKAST FORMULATIONS | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2022-01-20 | — | — | US | disclosed |
| US-6320052-B1 | CRYSTALLINE PRECURSORS OF 1-(((1(R)-(3-(2-(7-CHLORO-2-QUINO LYNYL)ETHENYL)PHENYL)-3-(2-HYDROXY-1-METHYL-ETHYL)PHENYL) PROPYL)THIO)METHYL)CYCLOPROPYLACETIC ACID | MERCK & CO., INC. | 2001-11-20 | — | — | US | disclosed |
| US-5856322-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, CARDIOVASCULAR DISORDERS | MERCK FROSST CANADA, INC. (CA) | 1999-01-05 | — | — | US | disclosed |
| EP-0737186-B1 | PROCESS FOR THE PREPARATION OF LEUKOTRIENE ANTAGONISTS | MERCK & CO INC (US) | 1998-08-19 | — | — | EP | disclosed |
| US-5614632-A | Process for the preparation of leukotriene anatgonists | MERCK & CO., INC. (US) | 1997-03-25 | — | — | US | disclosed |
| US-5565473-A | USEFUL AS ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND CYTOPROTECTIVE AGENTS; MONTELUKAST AND ITS SODIUM SALT | MERCK FROSST CANADA, INC. (CA) | 1996-10-15 | — | — | US | disclosed |
| US-5270324-A | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists | MERCK FROSST CANADA, INC. (CA) | 1993-12-14 | — | — | US | disclosed |
| EP-0480717-A1 | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1992-04-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11844861-B2 | Topical Montelukast formulations | CYSLTR1, CYSLTR2, SYMPK | CYSLTR1 1/4885CYP2C8 2537/4885CYSLTR2 2/4885 |
| US-12233055-B2 | Topical Montelukast formulations | CYSLTR1, CYSLTR2, SYMPK | CYSLTR1 1/4885CYP2C8 2326/4885CYSLTR2 2/4885 |
| US-20220016028-A1 | TOPICAL MONTELUKAST FORMULATIONS | CYSLTR1, CYSLTR2, SYMPK | CYSLTR1 1/4885CYP2C8 2537/4885CYSLTR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.