Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23755288 | 0.85 | CA12 (0.50) | TSHRRAB9ADAOPKMHTT | |
| SCHEMBL642078 | 0.83 | CA12 (0.42) | TSHRKDM4EALDH1A1GAARAB9A | |
| Lithium Ion SCHEMBL30122475 | 0.82 | CA12 (0.47) | TSHRALDH1A1RAB9ADAOPKM | |
| SCHEMBL25582307 | 0.78 | KDM4E (0.40) | TSHRKDM4EALDH1A1GAARAB9A | |
| SCHEMBL8830887 | 0.73 | KDM4E (0.63) | TSHRKDM4EALDH1A1GAARAB9A | |
| SCHEMBL29329332 | 0.73 | KDM4E (0.58) | TSHRKDM4EALDH1A1GAARAB9A | |
| SCHEMBL17866230 | 0.72 | KDM4E (0.43) | TSHRKDM4EALDH1A1GAARAB9A | |
| SCHEMBL12096318 | 0.72 | KDM4E (0.43) | TSHRKDM4EALDH1A1GAARAB9A | |
| SCHEMBL644865 | 0.72 | KDM4E (0.53) | TSHRKDM4EALDH1A1GAARAB9A | |
| 3,4,5-Triacetoxybenzoic Acid SCHEMBL716891 | 0.70 | KDM4E (0.63) | TSHRKDM4EALDH1A1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-B1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | PFIZER PROD INC (US) | 2014-06-11 | — | — | EP | disclosed |
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |