Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL643757 | 0.87 | GCK (0.47) | GCKKCNH2PTGS2SLC6A4ALDH1A1 | |
| SCHEMBL9902287 | 0.83 | GCK (0.42) | GCKKCNH2SLC6A4ALDH1A1HPGD | |
| SCHEMBL643724 | 0.81 | GCK (0.64) | GCKKCNH2 | |
| SCHEMBL9902848 | 0.81 | GCK (0.49) | GCKKCNH2PTGS2SLC6A4SCN9A | |
| SCHEMBL644656 | 0.81 | GCK (0.49) | GCKKCNH2PTGS2SLC6A4HAO1 | |
| SCHEMBL643859 | 0.80 | GCK (0.57) | GCKKCNH2 | |
| SCHEMBL642898 | 0.80 | GCK (0.56) | GCKKCNH2 | |
| SCHEMBL644515 | 0.80 | GCK (0.56) | GCKKCNH2 | |
| SCHEMBL12096277 | 0.80 | GCK (0.48) | GCKKCNH2PTGS2SLC6A4HAO1 | |
| SCHEMBL645021 | 0.79 | GCK (0.49) | GCKKCNH2PTGS2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-B1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | PFIZER PROD INC (US) | 2014-06-11 | — | — | EP | disclosed |
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |