Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL643528 | 0.86 | GCK (0.48) | GCKKCNH2PTGS2SLC6A4POLB | |
| SCHEMBL644656 | 0.82 | GCK (0.49) | GCKKCNH2PTGS2SLC6A4HAO1 | |
| SCHEMBL12096277 | 0.81 | GCK (0.48) | GCKKCNH2PTGS2SLC6A4HAO1 | |
| SCHEMBL9902275 | 0.81 | MRGPRX4 (0.38) | GCKKCNH2POLBL3MBTL1TTR | |
| SCHEMBL643936 | 0.81 | GCK (0.48) | GCKKCNH2PTGS2SLC6A4HAO1 | |
| SCHEMBL9903102 | 0.81 | GCK (0.48) | GCKKCNH2PTGS2SLC6A4HAO1 | |
| SCHEMBL2645481 | 0.79 | GCK (0.46) | GCKKCNH2PTGS2SLC6A4HAO1 | |
| SCHEMBL644143 | 0.76 | POLB (0.44) | GCKKCNH2PTGS2SLC6A4HAO1 | |
| SCHEMBL645021 | 0.74 | GCK (0.49) | GCKKCNH2PTGS2POLB | |
| SCHEMBL2644024 | 0.74 | PTGS2 (0.43) | GCKKCNH2PTGS2SLC6A4HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-B1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | PFIZER PROD INC (US) | 2014-06-11 | — | — | EP | disclosed |
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |