Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 16/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | VDR | P11473 | 1/20 | 0.35 |
| ▸ | FABP1 | P07148 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13222684 | 0.80 | FFAR1 (0.44) | NR1H4FFAR1HPGDVDRFABP1 | |
| SCHEMBL3053045 | 0.80 | FFAR1 (0.44) | NR1H4FFAR1HPGDVDRFABP1 | |
| SCHEMBL9903728 | 0.78 | SMN1; SMN2 (0.38) | NR1H4FFAR1HPGDPOLB | |
| SCHEMBL13243314 | 0.76 | NR1H4 (0.36) | NR1H4FFAR1HPGDVDRFABP1 | |
| SCHEMBL13243700 | 0.76 | NR1H4 (0.36) | NR1H4FFAR1HPGDVDRFABP1 | |
| SCHEMBL18632583 | 0.65 | NPC1 (0.41) | FFAR1POLB | |
| SCHEMBL29423933 | 0.64 | FFAR1 (0.41) | FFAR1 | |
| SCHEMBL9921313 | 0.63 | HPGD (0.34) | NR1H4FFAR1HPGDVDRPOLB | |
| SCHEMBL3063569 | 0.63 | FFAR1 (0.44) | FFAR1HPGDPOLB | |
| SCHEMBL9921259 | 0.63 | FFAR1 (0.44) | FFAR1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215068-B1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2012-06-13 | — | — | EP | disclosed |