Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 10/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.36 |
| ▸ | HPD | P32754 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29423931 | 0.85 | FFAR1 (0.36) | FFAR1ADAM17ALOX5 | |
| SCHEMBL29423946 | 0.80 | CDK8 (0.37) | FFAR1 | |
| SCHEMBL29423937 | 0.75 | FFAR1 (0.34) | FFAR1 | |
| SCHEMBL18940289 | 0.74 | FFAR1 (0.48) | FFAR1HPDMRGPRX4 | |
| SCHEMBL18632583 | 0.69 | NPC1 (0.41) | FFAR1MRGPRX4 | |
| SCHEMBL29423909 | 0.65 | MAOB (0.47) | FFAR1MAOAMAOBMRGPRX4 | |
| SCHEMBL18632561 | 0.65 | SHBG (0.40) | NPSR1 | |
| SCHEMBL24650797 | 0.62 | CHRNB2 (0.43) | FFAR1 | |
| SCHEMBL7038455 | 0.61 | GAA (0.56) | NPSR1 | |
| SCHEMBL4611333 | 0.61 | HPGD (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3974413-A1 | ANTIDIABETIC SUBSTITUTED HETEROARYL COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2022-03-30 | — | — | EP | disclosed |