Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 14/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9904042 | 0.87 | PDE10A (0.56) | PDE10AMAPK14 | |
| SCHEMBL9104339 | 0.86 | PDE10A (0.56) | PDE10A | |
| SCHEMBL9904424 | 0.85 | PDE10A (0.60) | PDE10A | |
| SCHEMBL9107517 | 0.84 | PDE10A (0.47) | PDE10A | |
| SCHEMBL9926258 | 0.84 | PDE10A (0.56) | PDE10A | |
| SCHEMBL9105822 | 0.84 | PDE10A (0.59) | PDE10A | |
| SCHEMBL9926239 | 0.83 | PDE10A (0.59) | PDE10A | |
| SCHEMBL9904177 | 0.83 | PDE10A (0.57) | PDE10A | |
| SCHEMBL9105607 | 0.82 | PDE10A (0.61) | PDE10A | |
| SCHEMBL9926271 | 0.82 | PDE10A (0.50) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649070-B1 | TRIAZOLOPYRIDINE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2014-09-17 | — | — | EP | disclosed |
| EP-2649070-A1 | TRIAZOLOPYRIDINE COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076430-A1 | TRIAZOLOPYRIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-14 | — | — | WO | disclosed |