Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 15/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103190 | 0.80 | PLA2G7 (0.43) | PLA2G7ADORA2AADORA1 | |
| SCHEMBL9904824 | 0.70 | PLA2G7 (0.39) | PLA2G7 | |
| SCHEMBL28095903 | 0.69 | PLA2G7 (0.47) | PLA2G7 | |
| SCHEMBL4415229 | 0.68 | PLA2G7 (0.43) | PLA2G7PNP | |
| SCHEMBL17226664 | 0.66 | PLA2G7 (0.34) | PLA2G7 | |
| SCHEMBL8404454 | 0.64 | — | — | |
| SCHEMBL28096269 | 0.64 | PLA2G7 (0.45) | PLA2G7 | |
| SCHEMBL9106022 | 0.64 | PLA2G7 (0.67) | PLA2G7 | |
| SCHEMBL27756202 | 0.62 | HTT (0.49) | PLA2G7 | |
| SCHEMBL28096268 | 0.62 | PLA2G7 (0.38) | PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |