Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.37 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.37 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.37 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.37 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.35 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905327 | 1.00 | P2RY14 (0.38) | P2RY14HDAC6MAPK1MAP2K4MAPK6 | |
| SCHEMBL9905817 | 0.90 | TP53 (0.37) | P2RY14HDAC6MAPK1TRPV1TLR7 | |
| SCHEMBL9905819 | 0.90 | TP53 (0.37) | P2RY14HDAC6MAPK1TRPV1TLR7 | |
| SCHEMBL17088958 | 0.88 | DAO (0.37) | P2RY14MAPK1MAP2K4MAPK6MAPKAPK3 | |
| SCHEMBL9921034 | 0.87 | HDAC6 (0.39) | P2RY14HDAC6MAPK1MAP2K4MAPK6 | |
| SCHEMBL18558594 | 0.87 | HDAC6 (0.39) | P2RY14HDAC6TRPV1PDE2APRKAB2 | |
| SCHEMBL18558030 | 0.86 | GRM5 (0.41) | P2RY14KDM4ETRPV1SNCAPDE2A | |
| SCHEMBL9905358 | 0.85 | SNCA (0.48) | P2RY14HDAC6MAPK1MAP2K4MAPK6 | |
| SCHEMBL9905362 | 0.85 | SNCA (0.48) | P2RY14HDAC6MAPK1MAP2K4MAPK6 | |
| SCHEMBL18558333 | 0.83 | SNCA (0.41) | P2RY14HDAC6KDM4ESNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648511-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | Lycera Corporation (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078874-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |