Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 3/20 | 0.48 |
| ▸ | ACR | P10323 | 3/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.35 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.35 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905358 | 1.00 | SNCA (0.48) | SNCAACRP2RY14ADORA3HDAC6 | |
| SCHEMBL18558123 | 0.92 | SNCA (0.41) | SNCAACRP2RY14ADORA3HDAC6 | |
| SCHEMBL18558333 | 0.92 | SNCA (0.41) | SNCAACRP2RY14ADORA3HDAC6 | |
| SCHEMBL18558030 | 0.91 | GRM5 (0.41) | SNCAACRP2RY14KDM4EMAPT | |
| SCHEMBL18558516 | 0.90 | HDAC3 (0.39) | SNCAACRHDAC6ALPLCA12 | |
| SCHEMBL18558124 | 0.90 | ALPL (0.41) | SNCAACRP2RY14ADORA3HDAC6 | |
| SCHEMBL9905271 | 0.90 | SNCA (0.41) | SNCAACRHDAC6KDM4EMAPT | |
| SCHEMBL9905267 | 0.90 | SNCA (0.41) | SNCAACRHDAC6KDM4EMAPT | |
| SCHEMBL17089717 | 0.90 | SNCA (0.41) | SNCAACRP2RY14ADORA3HDAC6 | |
| SCHEMBL17088959 | 0.89 | SNCA (0.44) | SNCAACRHDAC6ALPLCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648511-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | Lycera Corporation (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078874-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |