Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561524 | 0.82 | HTR6 (0.74) | HTR6HTR1ADRD2HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL2197493 | 0.81 | HTR6 (0.72) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL4690981 | 0.81 | HTR6 (0.61) | HTR6HTR1ADRD2HTR2AHTR7 | |
| Intepirdine SCHEMBL1683964 | 0.78 | HTR6 (1.00) | HTR6HTR1ADRD2HTR2AHTR7 | |
| Intepirdine SCHEMBL29355057 | 0.78 | HTR6 (1.00) | HTR6HTR1ADRD2HTR2AHTR7 | |
| Intepirdine SCHEMBL2197942 | 0.77 | HTR6 (0.98) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3562060 | 0.76 | HTR6 (0.67) | HTR6HTR1ADRD2HTR2AHTR7 | |
| Intepirdine SCHEMBL4907056 | 0.75 | HTR6 (0.88) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3561667 | 0.75 | HTR6 (0.91) | HTR6HTR1ADRD2HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL2196218 | 0.75 | HTR6 (0.66) | HTR6HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956004-B1 | Quinoline derivatives and their use as 5-HT6 ligands | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | claimed |