Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 3/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | LIPC | P11150 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901002 | 0.82 | LIPG (0.44) | SCN9ANOTUMLIPGMGLLABHD6 | |
| SCHEMBL9901277 | 0.80 | PTGER4 (0.48) | SCN9ANOTUMLIPGMGLLABHD6 | |
| SCHEMBL9901603 | 0.79 | SCN10A (0.49) | SCN9ANOTUMLIPGMGLLABHD6 | |
| SCHEMBL15294748 | 0.79 | DHODH (0.48) | SCN9ANOTUMLIPGMGLLABHD6 | |
| SCHEMBL9905719 | 0.78 | SCN9A (0.44) | SCN9ANOTUMLIPGMGLLABHD6 | |
| SCHEMBL9923507 | 0.73 | LIPG (0.53) | SCN9ALIPGMGLLABHD6ACACB | |
| SCHEMBL9901292 | 0.73 | SCN9A (0.44) | SCN9ALIPGDHODHACACB | |
| SCHEMBL9901949 | 0.71 | PTGER4 (0.45) | SCN9ALIPGMGLLABHD6DHODH | |
| SCHEMBL15294743 | 0.70 | SCN9A (0.44) | SCN9ANOTUMLIPGDHODHACACB | |
| SCHEMBL9900671 | 0.69 | LIPG (0.50) | SCN9ALIPGMGLLABHD6ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649061-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Rottapharm S.p.A. (IT) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076063-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | ROTTAPHARM S.P.A. (IT) | 2012-06-14 | — | — | WO | disclosed |