Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988861 | 0.83 | PIK3CA (0.61) | PIK3CAPIK3CB | |
| SCHEMBL1041397 | 0.80 | PIK3CA (0.76) | PIK3CAPIK3CB | |
| SCHEMBL989431 | 0.76 | PIK3CA (0.80) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL1040881 | 0.74 | PIK3CA (0.77) | PIK3CAPIK3CB | |
| SCHEMBL1038682 | 0.74 | PIK3CA (0.66) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL12535008 | 0.72 | PIK3CA (0.66) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL989463 | 0.71 | PIK3CA (0.54) | PIK3CAPIK3CBNOTUMDYRK1A | |
| SCHEMBL13655395 | 0.71 | PIK3CA (0.67) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL989272 | 0.71 | PIK3CA (1.00) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL12535854 | 0.71 | PIK3CA (0.70) | PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-B1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2014-05-07 | — | — | EP | claimed |
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | claimed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | claimed |
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |