Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 13/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 13/20 | 0.57 |
| ▸ | PRKCH | P24723 | 12/20 | 0.57 |
| ▸ | PRKCE | Q02156 | 12/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 12/20 | 0.57 |
| ▸ | PRKCB | P05771 | 11/20 | 0.57 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 8/20 | 0.43 |
| ▸ | JAK1 | P23458 | 5/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989940 | 0.88 | PRKCH (0.61) | PRKCAPRKCQPRKCHPRKCEPRKCD | |
| SCHEMBL989017 | 0.86 | PRKCA (0.66) | PRKCAPRKCQPRKCHPRKCEPRKCD | |
| SCHEMBL990596 | 0.86 | PRKCA (0.60) | PRKCAPRKCQPRKCHPRKCEPRKCD | |
| SCHEMBL12949132 | 0.83 | PRKCA (0.56) | PRKCAPRKCQPRKCHPRKCEPRKCD | |
| SCHEMBL990023 | 0.82 | PRKCA (0.57) | PRKCAPRKCQPRKCHPRKCEPRKCD | |
| SCHEMBL991235 | 0.82 | PRKCH (0.61) | PRKCAPRKCQPRKCHPRKCEPRKCD | |
| SCHEMBL3555948 | 0.82 | PRKCA (0.60) | PRKCAPRKCQPRKCHPRKCEPRKCD | |
| SCHEMBL4357973 | 0.80 | PRKCA (0.60) | PRKCAPRKCQPRKCHPRKCEPRKCD | |
| SCHEMBL990658 | 0.80 | PRKCH (0.62) | PRKCAPRKCQPRKCHPRKCEPRKCD | |
| SCHEMBL989139 | 0.79 | JAK3 (0.57) | PRKCAPRKCQPRKCHPRKCEPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270001-A1 | Indolylmaleimide derivatives as PKC inhibitors | Novartis AG (CH) | 2011-01-05 | — | — | EP | claimed |
| US-7648989-B2 | Indolylmaleimide derivatives as PKC inhibitors | NOVARTIS AG (CH) | 2010-01-19 | — | — | US | claimed |
| US-20080242675-A1 | Indolylmaleimide Derivatives as Pkc Inhibitors | NOVARTIS AG (CH) | 2008-10-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242675-A1 | Indolylmaleimide Derivatives as Pkc Inhibitors | PRKCE, PRKCH, PRKCI | PRKCA 4/4885PRKCQ 8/4885PRKCH 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.