Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.69 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.69 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.54 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.47 |
| ▸ | OGA | O60502 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL820825 | 0.83 | HTR3A (0.64) | HTR3AHRH4HCRTR1HCRTR2PDE10A | |
| SCHEMBL30824484 | 0.83 | HTR3A (0.73) | HTR3AHRH4HCRTR1HCRTR2TSHR | |
| SCHEMBL5508534 | 0.83 | HTR3A (0.73) | HTR3AHRH4HCRTR1HCRTR2TSHR | |
| SCHEMBL29648042 | 0.83 | HTR3A (0.73) | HTR3AHRH4HCRTR1HCRTR2TSHR | |
| SCHEMBL603314 | 0.82 | HTR3A (1.00) | HTR3AHRH4HCRTR1HCRTR2TSHR | |
| SCHEMBL3776403 | 0.81 | HTR3A (0.71) | HTR3AHRH4HCRTR1HCRTR2TSHR | |
| SCHEMBL31691646 | 0.81 | HTR3A (0.71) | HTR3AHRH4HCRTR1HCRTR2TSHR | |
| SCHEMBL3551319 | 0.80 | HTR3A (0.69) | HTR3AHRH4HCRTR1HCRTR2PDE10A | |
| SCHEMBL6931564 | 0.79 | HCRTR1 (0.62) | HTR3AHRH4HCRTR1HCRTR2TSHR | |
| SCHEMBL2420211 | 0.79 | HTR3A (0.67) | HTR3AHRH4HCRTR1HCRTR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012074980-A2 | METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISORDERS AND LIVER DISORDERS USING INDANE ACETIC ACID DERIVATIVES | DARA BIOSCIENCES, INC. (US) | 2012-06-07 | — | — | WO | disclosed |
| WO-2010141696-A1 | METHODS OF TREATING OR PREVENTING PSORIASIS, AND/OR ALZHEIMER'S DISEASE USING INDANE ACETIC ACID DERIVATIVES | DARA BIOSCIENCES, INC. (US) | 2010-12-09 | — | — | WO | disclosed |