Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.53 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.53 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.53 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 8/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707715 | 0.95 | PTK2 (0.58) | GSK3ALRRK2MAPK15CAMKK2PTK2 | |
| SCHEMBL1708502 | 0.90 | GLO1 (0.65) | GSK3ALRRK2MAPK15CAMKK2PTK2 | |
| SCHEMBL1706914 | 0.90 | PTK2 (0.58) | GSK3ALRRK2MAPK15CAMKK2PTK2 | |
| SCHEMBL9911243 | 0.89 | ZAP70 (0.55) | PTK2EGFRMAPK3ALK | |
| SCHEMBL9911242 | 0.89 | EGFR (0.55) | LRRK2PTK2EGFRMAPK3ALK | |
| SCHEMBL1707236 | 0.89 | EGFR (0.55) | LRRK2PTK2EGFRMAPK3ALK | |
| SCHEMBL1707581 | 0.88 | GSK3A (0.51) | GSK3ALRRK2MAPK15CAMKK2PTK2 | |
| SCHEMBL12726559 | 0.86 | GLO1 (0.56) | GSK3ALRRK2MAPK15CAMKK2PTK2 | |
| SCHEMBL1035767 | 0.86 | GLO1 (0.60) | GSK3ALRRK2MAPK15CAMKK2PTK2 | |
| SCHEMBL1707362 | 0.84 | EGFR (0.50) | LRRK2GLO1EGFRMAPK3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142667-A1 | PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142667-A1 | PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS | ZAP70, LCK, DPY30 | GSK3A 1621/4885LRRK2 3072/4885MAPK15 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.