Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.72 |
| ▸ | NPC1 | O15118 | 11/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.72 |
| ▸ | PKM | P14618 | 5/20 | 0.72 |
| ▸ | TP53 | P04637 | 3/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15022003 | 0.85 | RAB9A (0.78) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL880411 | 0.84 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL15688417 | 0.83 | RAB9A (0.60) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL27886383 | 0.79 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL10639656 | 0.79 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL2658434 | 0.78 | NPC1 (1.00) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL29236673 | 0.75 | NPC1 (0.58) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL5391772 | 0.75 | NPC1 (0.73) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL7684606 | 0.75 | NPC1 (0.61) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL7112763 | 0.73 | NPC1 (0.71) | RAB9ANPC1SMN1; SMN2PKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140364467-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-12-11 | — | — | US | disclosed |
| US-8778940-B2 | Chemical inducers of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130143935-A1 | STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-06-06 | — | — | US | disclosed |
| US-20130143885-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-06-06 | — | — | US | disclosed |
| US-8193225-B2 | Isoxazole amides, derivatives and methods of chemical induction of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-06-05 | — | — | US | disclosed |
| US-20120029200-A1 | Stem Cell Differentiating Agents and Uses Therefor | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-02-02 | — | — | US | disclosed |
| US-7981935-B2 | Stem cell differentiating agents and uses therefor | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-07-19 | — | — | US | disclosed |
| US-20090076103-A1 | STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-03-19 | — | — | US | disclosed |
| US-20090036451-A1 | Chemical inducers of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029200-A1 | Stem Cell Differentiating Agents and Uses Therefor | MYADM, MCL1, NOTCH4 | RAB9A 2887/4885NPC1 1970/4885SMN1; SMN2 2388/4885 |
| US-20090076103-A1 | STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR | MYADM, MCL1, NOTCH4 | RAB9A 2887/4885NPC1 1970/4885SMN1; SMN2 2388/4885 |
| US-20140364467-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | DCX, NES, GAP43 | RAB9A 2878/4885NPC1 1941/4885SMN1; SMN2 929/4885 |
| US-20090036451-A1 | Chemical inducers of neurogenesis | DCX, NES, GAP43 | RAB9A 2878/4885NPC1 1941/4885SMN1; SMN2 929/4885 |
| US-20130143935-A1 | STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR | MYADM, MCL1, NOTCH4 | RAB9A 2887/4885NPC1 1970/4885SMN1; SMN2 2388/4885 |
| US-20130143885-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | DCX, NES, GAP43 | RAB9A 2878/4885NPC1 1941/4885SMN1; SMN2 929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.