SCHEMBL9912150

SCHEMBL9912150

Nc1ccc(-c2ccc(N)s2)s1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP2E1 P05181 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2A6 P11509 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2B6 P20813 1/20 0.50
CYP2C19 P33261 1/20 0.50
APP P05067 3/20 0.41
NPC1 O15118 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
GFER P55789 1/20 0.31
HSD17B10 Q99714 1/20 0.31
LTA4H P09960 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17676915 0.97 CYP2E1 (0.48) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL3079941 0.81
SCHEMBL10029744 0.78 LTA4H (0.55) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL9912044 0.78 APP (0.76) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL5439237 0.78 CYP3A4 (0.61) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL61713 0.76 DPP4 (0.56) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL20461849 0.76 CYP3A4 (0.44) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
Hydrochloric Acid SCHEMBL9097933 0.76 CYP3A4 (0.59) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL31707921 0.75 CYP2A6 (0.49) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL3248713 0.74 CYP2D6 (0.62) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104086773-A Chiral polysilsesquioxane containing arylidene in skeleton and preparation method and application thereof UNIV SOOCHOW 2014-10-08 CN claimed
EP-3006486-B1 NOVEL BRANCHED OLIGOARYLSILANES AND METHOD FOR PRODUCING SAME LUMINESCENT INNOVATION TECH LIMITED LIABILITY COMPANY (RU) 2018-08-08 EP disclosed
CN-104086773-A Chiral polysilsesquioxane containing arylidene in skeleton and preparation method and application thereof UNIV SOOCHOW 2014-10-08 CN disclosed
WO-2012074437-A2 SUBSTITUTED AZOLES, ANTI-VIRAL ACTIVE INGREDIENT, PHARMACEUTICAL COMPOSITION, METHOD FOR THE PRODUCTION AND USE THEREOF АЛЛА ХЕМ, ЛЛС (US) 2012-06-07 WO disclosed
WO-2011105700-A1 NOVEL ORGANIC ELECTROLUMINESCENT COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) 2011-09-01 WO disclosed