Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 5/20 | 0.51 |
| ▸ | LCK | P06239 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4500166 | 0.86 | PTGDR (0.51) | PTGDRLCKBTKROCK2ROCK1 | |
| SCHEMBL4501709 | 0.86 | PTGDR (0.70) | PTGDR | |
| SCHEMBL9912207 | 0.78 | PTGDR (0.51) | PTGDRLCKBTKMAPK14CNR1 | |
| SCHEMBL9912195 | 0.77 | PTGDR (0.41) | PTGDRMEN1KMT2A | |
| SCHEMBL13895066 | 0.76 | PTGDR (0.47) | PTGDRLCKBTKMAPK14KDM4E | |
| SCHEMBL14405092 | 0.75 | PTGDR (0.41) | PTGDRTP53 | |
| SCHEMBL4490256 | 0.72 | PTGDR (0.75) | PTGDRLCKBTKMAPK14 | |
| SCHEMBL10476050 | 0.70 | PTGDR (0.47) | PTGDRLCKBTKROCK2ROCK1 | |
| SCHEMBL4487437 | 0.70 | PTGDR (0.74) | PTGDR | |
| SCHEMBL4503611 | 0.69 | PTGDR (0.74) | PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193183-B2 | 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists | AVENTIS PHARMACEUTICALS INC. (US) | 2012-06-05 | — | — | US | disclosed |