Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22819558 | 0.88 | CYP2C19 (0.41) | POLBHIF1ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL12251281 | 0.83 | POLB (0.52) | POLBCYP2D6HTR1DTSHRCYP3A4 | |
| SCHEMBL22915643 | 0.82 | CYP2C19 (0.38) | POLBHIF1ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL29419466 | 0.82 | CYP2C19 (0.38) | POLBHIF1ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13550117 | 0.80 | RAPGEF4 (0.42) | HIF1ATSHRCYP3A4ALOX15HPGD | |
| SCHEMBL29282560 | 0.78 | CHEK1 (0.46) | POLBHIF1ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL25888235 | 0.76 | POLB (0.46) | POLBHIF1ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL14410282 | 0.75 | POLB (0.44) | POLBHIF1ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL31414639 | 0.75 | HIF1A (0.38) | POLBHIF1ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL17594503 | 0.74 | POLB (0.44) | POLBHIF1ACYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198458-B2 | Non-nucleoside reverse transcriptase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-12 | — | — | US | disclosed |
| US-7517998-B2 | Benzothiazole or benzothiazine derivative of dipyrido(2,3;b:2',3'-e) diazepin-6-one; viricide against human t-cell leukemia/lymphoma virus | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2009-04-14 | — | — | US | disclosed |