Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9912429 | 0.87 | MEN1 (0.41) | MAPTKMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL9610085 | 0.86 | MAPT (0.65) | MAPTKMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL859927 | 0.74 | KMT2A (0.55) | MAPTKMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL9610108 | 0.73 | MEN1 (0.48) | MAPTKMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL846103 | 0.68 | MAPT (0.46) | MAPTKMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL15517362 | 0.62 | HSD17B10 (0.50) | MAPTKMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL11732818 | 0.61 | MAPT (0.45) | MAPTKMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL13949073 | 0.61 | ALDH1A1 (0.53) | MAPTKMT2AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL10508192 | 0.59 | KDM4E (0.50) | MAPTKMT2AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL16154469 | 0.58 | CYP2A6 (0.43) | MAPTSMN1; SMN2HSD17B10ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198458-B2 | Non-nucleoside reverse transcriptase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-12 | — | — | US | disclosed |