Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27805414 | 0.82 | PARP10 (0.43) | L3MBTL1ALDH1A1NPSR1KMT2ASMN1; SMN2 | |
| SCHEMBL11732040 | 0.81 | MAPT (0.49) | KDM4EALOX15L3MBTL1ALDH1A1MAPT | |
| SCHEMBL8516191 | 0.80 | KDM4E (0.38) | KDM4EALOX15L3MBTL1ALDH1A1MAPT | |
| SCHEMBL1111686 | 0.79 | MAPT (0.47) | KDM4EALOX15L3MBTL1ALDH1A1MAPT | |
| SCHEMBL30592770 | 0.79 | MAPT (0.47) | KDM4EALOX15L3MBTL1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL17674838 | 0.78 | MAPT (0.46) | KDM4EALOX15L3MBTL1ALDH1A1MAPT | |
| SCHEMBL7598688 | 0.75 | HPGD (0.52) | KDM4EL3MBTL1ALDH1A1GAANPSR1 | |
| SCHEMBL14398367 | 0.74 | KDM4E (0.60) | KDM4EALOX15L3MBTL1ALDH1A1MAPT | |
| SCHEMBL8539977 | 0.74 | MAPT (0.41) | KDM4EALOX15L3MBTL1ALDH1A1MAPT | |
| SCHEMBL7547389 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456774-A1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011009898-A1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-01-27 | — | — | WO | disclosed |