Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 17/20 | 0.60 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.60 |
| ▸ | METTL3 | Q86U44 | 4/20 | 0.58 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18922569 | 0.91 | PRMT5 (0.62) | PRMT5WDR77METTL3 | |
| SCHEMBL18659848 | 0.88 | PRMT5 (0.60) | PRMT5WDR77METTL3 | |
| SCHEMBL19540226 | 0.87 | PRMT5 (0.58) | PRMT5WDR77METTL3 | |
| SCHEMBL21937467 | 0.86 | DOT1L (0.58) | PRMT5WDR77METTL3DOT1L | |
| SCHEMBL23776679 | 0.85 | PRMT5 (0.56) | PRMT5WDR77METTL3 | |
| SCHEMBL10249394 | 0.85 | DOT1L (0.62) | PRMT5WDR77METTL3DOT1L | |
| SCHEMBL18571689 | 0.84 | PRMT5 (0.67) | PRMT5WDR77METTL3 | |
| SCHEMBL29323387 | 0.84 | PRMT5 (0.67) | PRMT5WDR77METTL3 | |
| SCHEMBL29325375 | 0.84 | PRMT5 (0.67) | PRMT5WDR77METTL3 | |
| SCHEMBL24465141 | 0.84 | PRMT5 (0.67) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012075381-A1 | SUBSTITUTED PURINE AND 7 - DEAZAPURINE COMPOUNDS AS MODULATORS OF EPIGENETIC ENZYMES | Epizyme, Inc. (US) | 2012-06-07 | — | — | WO | disclosed |