Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 17/20 | 0.67 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.67 |
| ▸ | AHCY | P23526 | 1/20 | 0.65 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.65 |
| ▸ | METTL3 | Q86U44 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24465141 | 1.00 | PRMT5 (0.67) | PRMT5WDR77AHCYADORA2BMETTL3 | |
| SCHEMBL29325375 | 1.00 | PRMT5 (0.67) | PRMT5WDR77AHCYADORA2BMETTL3 | |
| SCHEMBL29323387 | 1.00 | PRMT5 (0.67) | PRMT5WDR77AHCYADORA2BMETTL3 | |
| SCHEMBL9281381 | 0.90 | PRMT5 (0.67) | PRMT5WDR77METTL3 | |
| SCHEMBL9109059 | 0.90 | PRMT5 (0.67) | PRMT5WDR77METTL3 | |
| SCHEMBL25956773 | 0.87 | PRMT5 (0.69) | PRMT5WDR77METTL3 | |
| SCHEMBL18922569 | 0.86 | PRMT5 (0.62) | PRMT5WDR77METTL3 | |
| SCHEMBL18572585 | 0.85 | AHCY (0.52) | PRMT5WDR77AHCYADORA2B | |
| SCHEMBL22002025 | 0.85 | AHCY (0.52) | PRMT5WDR77AHCYADORA2B | |
| SCHEMBL10186262 | 0.85 | AHCY (0.52) | PRMT5WDR77AHCYADORA2BMETTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017032840-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | disclosed |