Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 13/20 | 0.49 |
| ▸ | GUCY1A1 | Q02108 | 5/20 | 0.43 |
| ▸ | GUCY1B1 | Q02153 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264700 | 0.92 | PDE5A (0.49) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL15519988 | 0.91 | ADORA3 (0.51) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL326783 | 0.89 | ADORA3 (0.54) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL9914002 | 0.80 | PDE5A (0.53) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL326641 | 0.78 | ADORA3 (0.58) | ADORA3KCNH2PDE5A | |
| SCHEMBL9913968 | 0.78 | ADORA3 (0.56) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL9913971 | 0.77 | ADORA3 (0.56) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL9913977 | 0.75 | GUCY1A1 (0.53) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL16245071 | 0.74 | GUCY1A1 (0.52) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL15120862 | 0.74 | ADORA3 (0.52) | ADORA3KCNH2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004258-A9 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012004258-A1 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-12 | — | — | WO | disclosed |