Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL326700 | 0.94 | PDE5A (0.55) | PDE5A | |
| SCHEMBL9913960 | 0.90 | ADORA3 (0.51) | PDE5A | |
| SCHEMBL9913987 | 0.89 | PDE5A (0.42) | PDE5A | |
| SCHEMBL9913940 | 0.89 | PDE5A (0.49) | PDE5A | |
| SCHEMBL16370352 | 0.88 | PDE5A (0.57) | PDE5A | |
| SCHEMBL15111571 | 0.88 | PDE5A (0.57) | PDE5A | |
| SCHEMBL15937792 | 0.88 | PDE5A (0.45) | PDE5A | |
| SCHEMBL15944482 | 0.88 | PDE5A (0.43) | PDE5A | |
| SCHEMBL14488226 | 0.86 | PDE5A (0.42) | PDE5A | |
| SCHEMBL16370287 | 0.86 | PDE5A (0.55) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216978-B2 | Ring-fused pyrimidines and triazines and use thereof for the treatment and/or prophylaxis of cardiovascular diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-22 | — | — | US | disclosed |
| US-9216978-B2 | Ring-fused pyrimidines and triazines and use thereof for the treatment and/or prophylaxis of cardiovascular diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-22 | — | — | US | disclosed |
| WO-2012004258-A9 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012004258-A1 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-12 | — | — | WO | disclosed |