SCHEMBL9915849

SCHEMBL9915849

COc1cc(/C=C/c2cc(OC)c(/C=C/c3cc(OC)c(C=O)cc3OC)cc2OC)c(OC)cc1C=O

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.78
KDM4E B2RXH2 2/20 0.78
TSHR P16473 1/20 0.78
TDP1 Q9NUW8 1/20 0.78
PRKDC P78527 2/20 0.57
CYP3A4 P08684 2/20 0.56
HMGCR P04035 1/20 0.56
LMNA P02545 1/20 0.55
HPGD P15428 1/20 0.55
MAPT P10636 2/20 0.55
NFE2L2 Q16236 2/20 0.53
CYP1A1 P04798 5/20 0.52
CYP1B1 Q16678 5/20 0.52
CYP1A2 P05177 4/20 0.52
ALOX15 P16050 1/20 0.50
HSD17B10 Q99714 1/20 0.50
ABCG2 Q9UNQ0 1/20 0.47
ERN1 O75460 3/20 0.47
GAA P10253 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3136850 0.93 ALDH1A1 (0.90) ALDH1A1KDM4ETSHRTDP1PRKDC
Asaraldehyde SCHEMBL333451 0.88 ALDH1A1 (1.00) ALDH1A1KDM4ETSHRTDP1PRKDC
Asaraldehyde SCHEMBL29456596 0.88 ALDH1A1 (1.00) ALDH1A1KDM4ETSHRTDP1PRKDC
Asaraldehyde SCHEMBL27489564 0.86 ALDH1A1 (0.95) ALDH1A1KDM4ETSHRTDP1PRKDC
SCHEMBL10849623 0.85 ALDH1A1 (0.86) ALDH1A1KDM4ETSHRTDP1PRKDC
SCHEMBL918825 0.85 CYP1A1 (0.61) ALDH1A1KDM4ETSHRTDP1MAPT
SCHEMBL918824 0.85 CYP1A1 (0.61) ALDH1A1KDM4ETSHRTDP1MAPT
SCHEMBL30865007 0.84 ALDH1A1 (0.75) ALDH1A1KDM4ETSHRTDP1PRKDC
SCHEMBL5698339 0.82 ALDH1A1 (0.81) ALDH1A1KDM4ETSHRTDP1PRKDC
SCHEMBL24311483 0.82 ALDH1A1 (0.72) ALDH1A1KDM4ETSHRTDP1PRKDC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8197722-B2 Irradiating the compound (containing two electron donor groups and a bridge of pi-conjugated bonds containing electron donor groups) with light, and the compound is converted to a multi-photon electronically excited state THE CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2012-06-12 US disclosed