Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 12/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30307024 | 1.00 | HRH1 (0.79) | HRH1KCNH2CYP2D6KDM4EPDE10A | |
| SCHEMBL29506217 | 0.93 | HRH1 (0.79) | HRH1KCNH2CYP2D6 | |
| SCHEMBL3793927 | 0.93 | HRH1 (0.79) | HRH1KCNH2CYP2D6 | |
| Bilastine SCHEMBL991810 | 0.92 | HRH1 (0.82) | HRH1KCNH2CYP2D6KDM4E | |
| Bilastine SCHEMBL29402994 | 0.92 | HRH1 (0.82) | HRH1KCNH2CYP2D6KDM4E | |
| Bilastine SCHEMBL21815518 | 0.90 | HRH1 (0.77) | HRH1KCNH2CYP2D6KDM4E | |
| Alinastine SCHEMBL142547 | 0.89 | HRH1 (1.00) | HRH1KCNH2 | |
| SCHEMBL4707799 | 0.87 | HRH1 (0.83) | HRH1KCNH2 | |
| SCHEMBL28422609 | 0.86 | HRH1 (0.75) | HRH1KCNH2CYP2D6KDM4E | |
| SCHEMBL28422607 | 0.85 | HRH1 (0.71) | HRH1KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0818454-B1 | Benzimidazole derivatives with antihistaminic activity | ESPANOLA DE PRODUCTOSQUIMICOS (ES) | 2004-04-14 | — | — | EP | claimed |
| US-5877187-A | Benzimidazole derivatives with antihistaminic activity | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS S.A. (FAES) (ES) | 1999-03-02 | — | — | US | claimed |
| EP-0818454-A1 | Benzimidazole derivatives with antihistaminic activity | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (FAES) (ES) | 1998-01-14 | — | — | EP | claimed |
| CN-107365297-B | Preparation method and intermediate of 2-methyl-2' -phenylpropionic acid derivative | 罗欣药业(上海)有限公司 | 2020-07-03 | — | — | CN | disclosed |
| US-8633223-B2 | Process for preparation of 2-methyl-2′-phenylpropionic acid derivatives and novel intermediate compounds | YUHAN CORPORATION (KR) | 2014-01-21 | — | — | US | disclosed |
| US-8487106-B2 | Process for preparation of 2-methyl-2′-phenylpropionic acid derivatives and novel intermediate compounds | YUHAN CORPORATION (KR) | 2013-07-16 | — | — | US | disclosed |
| US-20130116439-A1 | PROCESS FOR PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | YUHAN CORPORATION (KR) | 2013-05-09 | — | — | US | disclosed |
| US-20130116466-A1 | PROCESS FOR PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | YUHAN CORPORATION (KR) | 2013-05-09 | — | — | US | disclosed |
| US-8367704-B2 | Process for preparation of 2-methyl-2′ phenylpropionic acid derivatives and novel intermediate compounds | YUHAN CORPORATION (KR) | 2013-02-05 | — | — | US | disclosed |
| US-20110009636-A1 | PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | YUHAN CORPORATION (KP) | 2011-01-13 | — | — | US | disclosed |
| EP-2240464-A2 | PROCESS FOR PREPARATION OF 2-METHYL-2´-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | Yuhan Corporation (KR) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009102155-A2 | PROCESS FOR PREPARATION OF 2-METHYL-2´-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | YUHAN CORPORATION (KR) | 2009-08-20 | — | — | WO | disclosed |
| EP-1602354-A1 | HAIR TREATMENT COMPOSITION AND HAIR COSMETIC FOR DAMAGED HAIR | Meiji Seika Kaisha, Ltd. (JP) | 2005-12-07 | — | — | EP | disclosed |
| EP-0818454-B1 | Benzimidazole derivatives with antihistaminic activity | ESPANOLA DE PRODUCTOSQUIMICOS (ES) | 2004-04-14 | — | — | EP | disclosed |
| US-5877187-A | Benzimidazole derivatives with antihistaminic activity | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS S.A. (FAES) (ES) | 1999-03-02 | — | — | US | disclosed |
| EP-0818454-A1 | Benzimidazole derivatives with antihistaminic activity | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (FAES) (ES) | 1998-01-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009636-A1 | PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | HRH4, HCAR2, HRH1 | HRH1 3/4885KCNH2 945/4885CYP2D6 231/4885 |
| US-20130116439-A1 | PROCESS FOR PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | HRH2, HRH4, HNMT | HRH1 4/4885KCNH2 711/4885CYP2D6 238/4885 |
| US-20130116466-A1 | PROCESS FOR PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | HRH1, HRH2, HRH4 | HRH1 1/4885KCNH2 1065/4885CYP2D6 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.