Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12832878 | 0.86 | JAK2 (0.41) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL9894094 | 0.82 | JAK2 (0.39) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL12067323 | 0.66 | JAK2 (0.41) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL9980551 | 0.66 | JAK2 (0.46) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL12066103 | 0.65 | CD274 (0.39) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL12066107 | 0.64 | CD274 (0.40) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL9918681 | 0.64 | ADRA1D (0.43) | ADRA1DP2RX7PLA2G2ACCNCCDK8 | |
| SCHEMBL12066261 | 0.63 | JAK2 (0.46) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL12066104 | 0.62 | JAK1 (0.41) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL12067327 | 0.62 | JAK1 (0.41) | JAK2JAK1TYK2JAK3CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149662-A1 | Heterocyclic Compounds as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149662-A1 | Heterocyclic Compounds as Janus Kinase Inhibitors | JAK2, JAK1, JAK3 | JAK2 1/4885JAK1 2/4885TYK2 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.