⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL240846 | 0.73 | — | — | |
| SCHEMBL15017181 | 0.73 | — | — | |
| SCHEMBL1205841 | 0.73 | — | — | |
| SCHEMBL19560131 | 0.73 | — | — | |
| SCHEMBL1072255 | 0.71 | — | — | |
| SCHEMBL1629567 | 0.71 | — | — | |
| SCHEMBL28912275 | 0.70 | — | — | |
| SCHEMBL21323397 | 0.68 | HCAR2 (0.52) | — | |
| SCHEMBL4916584 | 0.68 | — | — | |
| SCHEMBL1204783 | 0.68 | HCAR2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024262911-A1 | NOVEL PYRAZOLO PYRIMIDINE-BASED COMPOUND AND USE THEREOF | 주식회사 에이조스바이오 | 2024-12-26 | — | — | WO | disclosed |
| EP-3706749-B1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS AND USES THEREOF | ANGEX PHARMACEUTICAL INC (US) | 2024-03-13 | — | — | EP | disclosed |
| CN-111971287-B | Macrocyclic compounds as TRK kinase inhibitors | 重庆复尚源创医药技术有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-115551863-A | Salt form, crystal form, pharmaceutical composition and application of tyrosine kinase inhibitor | 贝达药业股份有限公司 | 2022-12-30 | — | — | CN | disclosed |
| EP-3891152-A1 | TYROSINE KINASE INHIBITORS, COMPOSITIONS AND METHODS THERE OF | Betta Pharmaceuticals Co., Ltd (CN) | 2021-10-13 | — | — | EP | disclosed |
| WO-2021047584-A1 | SUBSTITUTED (2-AZABICYCLO [3.1.0] HEXAN-2-YL) PYRAZOLO [1, 5-a] PYRIMIDINE AND IMIDAZO [1, 2-b] PYRIDAZINE COMPOUNDS AS TRK KINASES INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2021-03-18 | — | — | WO | disclosed |
| EP-3774812-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASES INHIBITORS | Fochon Pharmaceuticals, Ltd. (CN) | 2021-02-17 | — | — | EP | disclosed |
| EP-3765462-A1 | SUBSTITUTED (2-AZABICYCLO [3.1.0] HEXAN-2-YL) PYRAZOLO [1, 5-A] PYRIMIDINE AND IMIDAZO [1, 2-B] PYRIDAZINE COMPOUNDS AS TRK KINASES INHIBITORS | Fochon Pharmaceuticals, Ltd. (CN) | 2021-01-20 | — | — | EP | disclosed |
| US-20200385386-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS AND USES THEREOF | ANGEX PHARMACEUTICAL, INC. | 2020-12-10 | — | — | US | disclosed |
| CN-111971287-A | Macrocyclic compounds as TRK kinase inhibitors | 重庆复创医药研究有限公司 | 2020-11-20 | — | — | CN | disclosed |
| EP-3706749-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS AND USES THEREOF | Angex Pharmaceutical, Inc. (US) | 2020-09-16 | — | — | EP | disclosed |
| WO-2020114499-A1 | TYROSINE KINASE INHIBITORS, COMPOSITIONS AND METHODS THERE OF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2020-06-11 | — | — | WO | disclosed |
| WO-2019184955-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASES INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2019-10-03 | — | — | WO | disclosed |
| WO-2019174598-A1 | SUBSTITUTED (2-AZABICYCLO [3.1.0] HEXAN-2-YL) PYRAZOLO [1, 5-a] PYRIMIDINE AND IMIDAZO [1, 2-b] PYRIDAZINE COMPOUNDS AS TRK KINASES INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2019-09-19 | — | — | WO | disclosed |
| EP-2967073-B9 | LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-3268367-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2018-01-17 | — | — | EP | disclosed |
| WO-2016144844-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2016-09-15 | — | — | WO | disclosed |
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011006074-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-2008013622-A2 | FUNGICIDAL AZOCYCLIC AMIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-01-31 | — | — | WO | disclosed |