Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 6/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 3/20 | 0.37 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9920486 | 1.00 | KDM4E (0.46) | KDM4EALDH1A1L3MBTL1GPR119PANK3 | |
| SCHEMBL9918884 | 0.86 | GRM5 (0.33) | KDM4EALDH1A1L3MBTL1PARP1RET | |
| SCHEMBL9918348 | 0.86 | GRM5 (0.33) | KDM4EALDH1A1L3MBTL1PARP1RET | |
| SCHEMBL9923396 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1L3MBTL1GPR119PANK3 | |
| SCHEMBL24296015 | 0.82 | RET (0.47) | KDM4EALDH1A1L3MBTL1GPR119PANK3 | |
| SCHEMBL22570975 | 0.82 | RET (0.47) | KDM4EALDH1A1L3MBTL1GPR119PANK3 | |
| SCHEMBL1021345 | 0.82 | RET (0.47) | KDM4EALDH1A1L3MBTL1GPR119PANK3 | |
| SCHEMBL9918355 | 0.80 | HRH3 (0.37) | GPR119PANK3 | |
| SCHEMBL26301186 | 0.80 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1GPR119PANK3 | |
| SCHEMBL9920475 | 0.78 | GPR119 (0.55) | KDM4EALDH1A1L3MBTL1GPR119PANK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | JAK1, JAK2, JAK3 | KDM4E 449/4885ALDH1A1 1632/4885L3MBTL1 4461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.